The focus of the Biomedical Computer Vision Laboratory (BCVL) is the computational analysis of microscopy images of cells and cellular processes. The head of BCVL and founder of the Center for BioEngineering (CBE) is Alex Matov, PhD.
CBE-BCVL is currently pursuing scientific projects in the areas of basic and translational research. These include several interdisciplinary collaborations encompassing computational science, applications of light microscopy as well as cell and cancer biology. Our expertise is in the design and development of computer vision algorithms for quantification of microscopy images, and in applying engineering approaches to investigating degenerative diseases.
Video: Organoids derived from high-risk primary and micro metastasis prostate as well as distant metastasis colorectal tumors. These cultures, derived from resected patient tissues, were established, treated with chemotherapy drugs ex vivo and imaged by Alexandre Matov at the University of California, San Francisco. Each organoid is a hundred to several hundred micrometers in diameter and is assembled by dozens of thousands of individual patient cells from slow-proliferating, genetically heterogeneous, drug-naïve tumors or aggressive, recurrent disease cells emerging after hormonal and radiation therapies. Small molecules and genetic manipulations, which are not feasible in vivo, can be performed in organoids, making them a unique, physiologically relevant resource for functional interrogation of drug response. The organoid culture system presents us with a fantastic opportunity to develop living biobanks for screening of panels of drugs approved for clinical use as well as discovery of novel compounds, which will provide the foundations of precision medicine and personalized patient care for all.
Presentation at the University of Information Science & Technology St Paul the Apostle, Ohrid. Motion analysis of fluorescently labeled polymerizing microtubule ends in interphase cancer cells treated with taxanes
Video presentation at the Center for Research in Computer Vision at the University of Central Florida, Orlando. Tracking antiparallel motion in microtubule & filamentous actin networks imaged by fluorescent speckle microscopy. Part II: Enumeration & analysis of circulating tumor cells from peripheral blood of metastatic prostate cancer patients.
Presentation at the Medical Faculty of the University Sts Cyril & Methodius, Skopje. Компјутерска анализа на динамиката на микротубулите за персонализирана хемотерапија