The focus of the Biomedical Computer Vision Laboratory (BCVL) is the computational analysis of microscopy images of cells and cellular processes. The head of the lab is Alexandre Matov, PhD.
BCVL is currently pursuing scientific projects in the areas of basic and translational research. These include several interdisciplinary collaborations encompassing computational science, applications of light microscopy, as well as cell and cancer biology. Our expertise is in the design and development of computer vision algorithms for quantification of fluorescence microscopy images, and in applying engineering principles and mathematical modeling to address human health and disease problems.
Presentation at the Medical Faculty in Skopje – Компјутерска анализа на динамиката на микротубулите за персонализирана хемотерапија
Presentation at UCF – Tracking antiparallel motion in microtubule & f-actin networks imaged by fluorescent speckle microscopy. Part II: Enumeration & analysis of circulating tumor cells from peripheral blood of metastatic prostate cancer patients.
Plebanek MP, Mutharasan RK, Matov A, Gatlin JC, Thaxton CS. High-density lipoprotein-like nanoparticles inhibit melanoma cell-derived exosome uptake by targeting SR-B1 and modulating cholesterol flux. TechConnect World Innovation 2015
Galletti G, Matov A, Beltran H, Fontugne J, Mosquera JM, Cheung C, MacDonald TY, Sung MS, O’Toole S, Kench JG, Chae SS, Kimovski D, Tagawa ST, Nanus DM, Rubin MA, Horvath L, Giannakakou P, Rickman DS. ERG induces taxane resistance in castration-resistant prostate cancer. Nature Communications, 2014 Nov 25;5:5548
Milunovic-Jevtic A, Hazel JH, Groen AC, Ishihara K, Marina N, Mitchison TJ, Matov A, Gatlin JC. Investigating microtubule growth dynamics in discrete cytoplasmic volumes. Molecular Biology of the Cell 24, American Society for Cell Biology 2013
Galletti G, Cleveland K, Matov A, Hayes JE, Klein RJ, Hassane DC, Nicacio LV, Giannakakou P, Shah M. Clinical and preclinical evaluation of taxane sensitivity in gastric cancer (GC): relevance of GC histology. J Clinical Oncology 31, 4(37), Gastrointestinal Cancers Symposium 2013
Matov A, Kimovski D, Galletti G, Pera B, Harkcom WT, Rickman DS, Giannakakou P. Computational analysis of microtubule dynamics for personalized cancer therapy. Cancer Research, 73 (8), American Association for Cancer Research 2013
Sung MS, Giyrezi A, Lee GY, Matov A, Galletti G, Loftus M, Syed Y, Lannin T, Hristov A, Mason C, Tagawa ST, Kirby B, Nanus DM, Giannakakou P. Using circulating tumor cells (CTCs) to interrogate mechanisms of taxane resistance in the prospective TAXYNERGY clinical trial in prostate cancer. Cancer Research, 73 (8), American Association for Cancer Research 2013
Matov A, Marina N. Analysis of unstructured crowded scenes: Instantaneous flow tracking algorithm (IFTA) applied to surveillance. Accepted at the Eilat, Israel IEEE Convention 2012
Sung MS, Gjyrezi A, Syed Y, Lannin T, Hristov A, Matov A, Loftus M, Galletti G, Lee GY, Mason C, Kirby B, Nanus DM, Tagawa ST, Giannakakou P. Molecular determinants of taxane activity using circulating tumor cells (CTCs) from castrate-resistant prostate cancer patients. Physical Sciences-Oncology Center on the Microenvironment & Metastasis, New York Academy of Medicine, Understanding Cancer: Genomes to Devices Symposium 2012